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Annual Report 2020

Research Funding

EU Research Grants

Ongoing projects in 2020 with funding of more than 1 million euros

Topic

Project Head

Amount Granted

 

 

KEUR

Efficacy and safety of thrombectomy in stroke with extended lesion and extended time window: a randomized, controlled trial (TENSION)

Prof. Dr. Martin Bendszus
Dr. Steffen Luntz

2,455

Establishment and Exploitation of a European-Latin American Research Consortium towards Eradication of Preventable Gallbladder Cancer (EULAT Eradicate GBC)

Prof. Dr. Justo Lorenzo Bermejo

2,362

Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial (NISCI)

Prof. Dr. Norbert Weidner
Dr. Steffen Luntz
Dr. Tanja Weiss

2,037

Penumbral Rescue by Normobaric O=O Administration in Patients With Ischaemic Stroke and Target Mismatch ProFile: A Phase II Proof-of-Concept Trial (PROOF)

Dr. Steffen Luntz

1,351

Reconciliation of Cohort Data for Infectious Diseases (RECODID)

PD Dr. Thomas Jänisch

1,237

A global alliance for Zika virus control and prevention (ZIKAlliance)

PD Dr. Thomas Jänisch

1,111

Ongoing ERC Grants in 2020

Topic

Project Head

Grant

Amount Granted

 

 

 

KEUR

Hypothalamic Mechanisms of Thermal Homeostasis and Adaptation (Acclimatize)

Prof. Dr. Jan-Erik Siemens

Consolidator Grant

1,903

Dry season P. falciparum reservoir (DrySeasonPf)

Dr. Silvia Portugal

Starting Grant

1,500

Improving health services to prevent heart attacks and strokes: Evidence for interventions (E4I) in large middle-income countries

Dr. Pascal Geldsetzer

Starting Grant

1,492

Research Grants from the German Federal Government

Ongoing projects in 2020 with funding of more than 1 million euros

Topic

Spokesperson

Total Amount Granted

 

 

KEUR

German Center for Cardiovascular Research

Prof. Dr. Hugo Katus

14,500

German Center for Lung Research

Prof. Dr. Markus Mall

13,316

German Center for Infection Research

Prof. Dr. Hans-Georg Kräusslich

13,033

HiGHmed Medical Informatics Consortium

Prof. Dr. Roland Eils
Prof. Dr. Christoph Dieterich

9,766

Adaptive Radiotherapy with Ion Beams (ARTEMIS)

Prof. Dr. Jürgen Debus

8,087

SMART-CARE: A systems medicine approach to stratify the relapse of cancer

Prof. Dr. Jeroen Krijgsveld
Prof. Dr. Carsten Müller-Tidow
Prof. Dr. Petra Knaup-Gregori
Prof. Dr. Julio Saez-Rodriguez
Prof. Dr. Peter Schirmacher
Prof. Dr. Andreas von Deimling
Prof. Dr. Sascha Dietrich

4,436

An integrated systems medicine approach to personalized and targeted therapy in leukemia and lymphoma (SYMPATHY)

Prof. Dr. Sascha Dietrich

3,085

Improvement of functional outcomes for patients with newly diagnosed grade II or III glioma with co-deletion of 1p/19q – IMPROVE CO-DEL: a NOA trial

Prof. Dr. Wolfgang Wick

2,948

DZHK TranslatiOnal Registry for CardiomyopatHies – Plus (DZHK TORCH-Plus)

Prof. Dr. Benjamin Meder

2,509

German Center for Diabetes Research

Prof. Dr. Peter Nawroth

2,250

A randomized open label phase-II Ccinical trial with or without infusion of plasma from subjects after convalescence of SARS-CoV-2 infection in high-risk patients with confirmed severe SARS-CoV-2 disease (RECOVER)

Prof. Dr. Carsten Müller-Tidow

2,150

LeukoSyStem – e:med Junior Research Alliance: Multi-scale, single-cell systems biology of leukemia stem cells in pathogenesis and therapy. Project B1: Single-cell multi-omic and metabolic characterization of leukemic stem cells to elucidate drivers of pathogenesis and therapy resistance at the single cell level leukemia

Dr. Simon Raffel

2,083

National cohorts, health survey
2nd funding phase

Prof. Dr. Hans-Ulrich Kauczor
Prof. Dr. Till Bärnighausen

2,032

Netzwerk Universitätsmedizin COVID-19:
B-FAST – Nationwide Research Network Applied Surveillance and Testing

Prof. Dr. Hans-Georg Kräusslich
Prof. Dr. Ralf Bartenschlager
Prof. Dr. Michael Knop
Prof. Dr. Till Bärnighausen
Dr. Claudia Denkinger
Prof. Dr. Georg-Friedrich Hoffmann

1,969

Liposomes as a platform technology for the oral delivery of macromolecular active ingredients (LipOra).

Dr. Philipp Uhl
Dr. Max Sauter

1,870

Development of a novel lipid-lowering agent to reduce cardio-vascular risk in hypercholesterolemia and metabolic syndrome (PrimaLiveR)

Dr. Volker Cleeves

1,782

Initial treatment of idiopathic nephrotic syndrome in children with mycophenolate mofetil vs. prednisone: A randomized, controlled, multicenter trial (INTENT Study)

Prof. Dr. Burkhard Tönshoff

2,018

Competence-oriented learning, teaching and testing in medicine; sub-project Heidelberg Medical Faculty (MERLIN II)

Dr. Andreas Möltner

1,420

Optimizing collaboration between primary care physicians and psychotherapists: A study on the implementation of video consultations (PROVIDE)

PD Dr. Markus Haun

1,286

The intergenerational cycle of family maltreatment: causes and prevention through health and social service interventions – 4 subprojects (UBICA II)

Prof. Dr. Sabine Herpertz
Prof. Dr. Svenja Taubner
Prof. Dr. Beate Ditzen
Dr. Steffen Luntz

1,225

German Biobanks Alliance / BBMRI.de – Heidelberg Site (GBS)

Prof. Dr. Peter Schirmacher

1,198

Research into promoting help-seeking behavior by adolescents with mental problems through the use of new media; central project VCP (Pro-HEAD)

Prof. Dr. Michael Kaess

1,191

Development and evaluation of context-specific interventions to improve health care for asylum seekers (RESPOND)

Dr. Kayvan Bozorgmehr

1,131

Development of the basis for a new understanding of the pathological processes in multiple sclerosis in the brain (NanoPatho) – Subproject: Correlative hierarchical 3D nano tomography

Prof. Dr. Rasmus Schröder

1,076

e:med Junior Research Alliance: MelBrainSys SP B.4: Model-based prediction and experimental validation of novel therapeutic interventions for melanoma brain metastases

Dr. Matthia Karreman

1,069

Participation in five German Health Research Centers

  • German Center for Cardiovascular Research
  • German Center for Lung Research
  • German Center for Infection Research
  • German Center for Diabetes Research
  • German Center for Translational Cancer Research

Collaborative Research Centers of the German Research Foundation

 

Title

Spokesperson

CRC 1118

Reactive metabolites as the cause of diabetic complications

Prof. Dr. Peter Nawroth

CRC 1129

Integrative Analysis of Pathogen Replication and Spread

Prof. Dr. Hans-Georg Kräusslich

CRC 1158

From nociception to chronic pain: Structural functional features of neuronal pathways and their reorganization

Prof. Dr. Rohini Kuner

CRC 1389

Overcoming the resistance to treatment of glioblastomas

Prof. Dr. Wolfgang Wick

CRC-TRR 83

Molecular architecture and cellular functions of lipid-protein complexes

Prof. Dr. Thomas Söllner

CRC-TRR 156

The skin as sensor and effector organ orchestrating local and systemic immune responses

Prof. Dr. Alexander Enk

CRC-TRR 179

Determinants and dynamics of elimination versus persistance of hepatitis virus infection

Prof. Dr. Ralf Bartenschlager

CRC-TRR 209

Liver cancer – new mechanistic and therapeutic concepts in a solid tumor model

Prof. Dr. Peter Schirmacher

 

Title

Sites

CRC 873

Maintenance and differentiation of stem cells in development and disease

Heidelberg

CRC 1036

Cellular surveillance and damage response

Heidelberg

CRC 1249

N-heteropolycycles as functional materials

Heidelberg

CRC 1324

Mechanisms and functions of Wnt signaling

Heidelberg

CRC 1366

Vascular control of organ function

Heidelberg

CRC 1425

Heterocellular Nature of Cardiac Lesions: Identities, Interactions, Implications

Heidelberg, Freiburg

CRC-TRR 152

TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules

München, Homburg, Freiburg, Heidelberg

CRC-TRR 186

Molecular switch for spatial and kinetic regulation of cellular signal transmission

Heidelberg, Berlin

Other major German Research Foundation projects

Ongoing projects in 2020 with funding of more than 500,000 euros

Topic

Spokesperson

Total Grant

 

 

KEUR

Emmy Noether
mTOR abhängige Wachstumskontrolle im Herzen

Dr. Mirko Völkers

1,909

Clinical trail
APOS Studie: Antibiotische Prophylaxe zur Vorbeugung von Infektionen nach Orthognather Umstellungsosteotomie

PD Dr. Dr. Oliver Ristow

1,789

Cluster of Excellence
CellNetworks Junior Research Group: Viral Infection

Dr. Pierre-Yves Lozach

1,418

Emmy Noether
Spatial periodicity of the grid cell: Necessary cellular interactions in development and functional relevance

Dr. Kevin Allen

1,217

Emmy Noether
Treatable metabolic weak spots in leukemic stem cells

Dr. Simon Raffel

1,153

Research Group 2407
Exploring Articular Cartilage and Subchondral Bone Degeneration and Regeneration in Osteoarthritis (ExCarBon)
TP 03: Bedeutung mechanosensitiver microRNAs für Knorpelfunktion und Pathophysiologie der Osteoarthrose

Prof. Dr. Wiltrud Richter

1,035

individual Research Grant
Prospektive Evaluierung residualer Erkrankung als Surrogat für Überlebensendpunkte bei intensiv behandelten Patienten mit akuter myeloischer Leukämie

Prof. Dr. Richard Schlenk

941

Clinical Trail
Reduktion der postoperativen Hernienrate nach Laparotomien durch small stitch Bauchdeckenverschluss ohne vs. mit prophylaktischer Netzimplantation (HULC)

Prof. Dr. André Mihaljevic

901

Priority program 1923
Innate Sensing and Restriction of Retroviruses
TP 08: Capsid-abhängige Erkennung und Restriktion retroviraler Replikationskomplexe

Prof. Dr. Hans-Georg Kräusslich

893

Priority program 1923
Innate Sensing and Restriction of Retroviruses; TP 03: Antagonism of host cell restriction and recognition by HIV-1 Nef

Prof. Dr. Oliver Fackler

665

Research Group 2936
Climate change and health in Africa south of the Sahara; TP ZP 01: Development and analysis of population cohorts in Burkina Faso and Kenya

Prof. Dr. Till Bärnighausen

637

individual Research Grant
Secondary use of clinical data for research and care – ethical, societal and legal aspects

Prof. Dr. Eva Winkler

615

Research Group 2928
Fluchtmigration nach Deutschland: ein „Vergrößerungsglas“ für umfassendere Herausforderungen im Bereich Public Health; TP 01: Natürliches Experiment zu kontextuellen Einflüssen auf die Gesundheit und Gesundheitsversorgung von Geflüchteten (NEXUS)

Prof. Dr. Kayvan Bozorgmehr

560

individual Research Grant
Proteomische und funktionelle Charakterisierung der wachstumsunterdrückenden Wirkung von Galektin-4 in Darmkrebszellen

Dr. Malwina Michalak

538

individual Research Grant
Monoallelic expression of proteinuria-associated CUBN variants for renal self-defense.

Prof. Dr. Matias Simons

535

Individual Research Grant
MicroRNA regulation of glucocorticoid-induced autophagy and progression of pancreatic ductal adenocarcinoma.

Prof. Dr. Ingrid Herr

533

individual Research Grant
Integrative analysis of nuclear division mechanisms in malaria parasite

Dr. Julien Guizetti

532

individual Research Grant
Exploring novel molecular mechanisms of TSC22D4 in development of diabetes mellitus

Dr. Bilgen Ekim Üstünel

516

Projects with other sponsors

Ongoing projects in 2020 with funding of more than one million euros

Supporter/Topic

Spokesperson

Total Grant

 

 

KEUR

Dietmar Hopp Stiftung: Heidelberg concept for the cure of multiple myeloma

Prof. Dr. Hartmut Goldschmidt

12,566

Dietmar Hopp Stiftung: Exploratory study to identify predictive biomarker signatures in patients with advanced non-small cell lung cancer (NSCLC)

Prof. Dr. Dirk Jäger

5,808

German Cancer Aid: Continued funding of the National Center for Tumor Diseases Heidelberg as part of the oncological centers of excellence funding program

Prof. Dr. Stefan Fröhling

3,000

Dietmar Hopp Stiftung: Pilot project for the development of personalized cellular immunotherapy in solid cancers.

Prof. Dr. Dirk Jäger

2,879

Joint Federal Committee (G-BA)
Improving the care of people with rare diseases by implementing measures consented to in the national action plan (NAMSE) / TRANSLATE-NAMSE

Prof. Georg F. Hoffmann
PD Dr. Daniela Choukair

2,428

National Institutes of Health (NIH): Rapid research for diagnostics development in TB network

PD Dr. Claudia Denkinger

2,322

Klaus Tschira Stiftung: Establishment of a sustainable real laboratory for interdisciplinary and translational research in the field of mathematical modeling and simulation in ophthalmology

Prof. Dr. Gerd Auffarth

2,178

Chica und Heinz Schaller Stiftung: Junior research group: Neuron-glia Interactions in neural circuits

Dr. Amit Agarwal

2,123

Forum Gesundheitsstandort Baden-Württemberg: Der Kognitive medizinische Assistent (KoMed) – Klinische Entscheidungsunterstützung durch künstliche Intelligenz auf höchster Datenqualität

Dr. Jan Larmann

2,050

Dietmar Hopp Stiftung: DATA 5.0 – Data Acquisition, Translation and Analysis

Prof. Dr. Markus Hohenfellner

2,000

Chica und Heinz Schaller Stiftung: Junior research group: Membrane biology of viral infection

Dr. Petr Chlanda

1,826

Ministerium für Soziales und Integration Baden-Württemberg: ARMED – Augmented Reality assisted, forensic Medical Evidence collection and Documentation

Prof. Dr. Kathrin Yen

1,811

Chica und Heinz Schaller Stiftung: Junior research group: Laboratory of neural circuits and behavior

Dr. Claudio D. Acuna Goycolea

1,785

Dietmar Hopp Stiftung: Newborn screening – optimization of diagnostic processes

Prof. Dr. Georg F. Hoffmann
apl. Prof. Dr. Jürgen Okun

1,785

Chica und Heinz Schaller Stiftung: Junior research group: Stem cell-derived culture models for hepatitis E virus studies

Dr. Viet Loan Dao Thi, Ph.D.

1,780

Joint Federal Committee (G-BA): PRiVENT – Früherkennung und Frühintervention bei Risikopatienten zur Vermeidung von invasiver Langzeitbeatmung

Prof. Dr. Joachim Szecsenyi

1,716

German Cancer Aid: Risiko-adaptierte Prostatakarzinom Früherkennung durch einen Basis-PSA Bestimmung bei jungen Männern von 45 Jahren (PROBASE)

Prof. Dr. Markus Hohenfellner

1,602

German Cancer Aid: Phase I/II Umbrella Study of molecular adapted treatments in combination with radiation therapy for patients with newly diagnosed glioblastoma without MGMT MGMT Promotor hypermethylation: NCT Neuro Master Match (N2M2)

Prof. Dr. Wolfgang Wick

1,500

Ministry for Science, Research and Art Baden-Württemberg:
Junior reseach group for pediatric precision oncology

Prof. Dr. Stefan Pfister
Dr. Kristian Pajtler

1,499

Ministry of Social Affairs Baden-Württemberg: ZPM-Netzwerk BW – Ausbildung einer regionalen Versorgungsstruktur der Personalisierten Medizin in Baden-Württemberg

Dr. Carolin Plöger

1,452

Joint Federal Committee (G-BA): Mind: Pregnancy – Online-basierte Achtsamkeitsintervention zur Stärkung psychischer Stabilität von Schwangeren und Förderung einer physiologischen Geburt

PD Dr. Stephanie Wallwiener

1,370

Joint Federal Committee (G-BA): ULCUS CRURIS CARE – Etablierung eines patientenorientierten, evidenzbasierten Versorgungskonzeptes für die Therapie des Ulcus cruris venosum in Hausarztpraxen mit praxisbasiertem Case-Management durch Medizinische Fachangestellte (VERAH) und Nutzung moderner IT-Unterstützung

Prof. Dr. Joachim Szecsenyi

1,367

Dietmar Hopp Stiftung: 2D-Druck von Arnzeimitteln für Kinder und Jugendliche

Prof. Dr. Walter Haefeli
Prof. Dr. Georg F. Hoffmann

1,360

Dietmar Hopp Stiftung: Neugeborenenscreening Langzeit Schul- und Jugendalter II

Prof. Dr. Stefan Kölker

1,213

Dietmar Hopp Stiftung: Further development of newborn screening

Prof. Dr. Georg F. Hoffmann

1,160

Federal Joint Committee (G-BA): Ensuring continuity of care: patient-oriented referral and discharge management in primary care practices and hospitals

Prof. Dr. Joachim Szecsenyi
Prof. Dr. Meinhard Kieser

1,113

Dietmar Hopp Stiftung: PACMAN – Intravenous vs. epidural analgesia to reduce the incidence of gastrointestinal complications after elective pancreatoduodenectomy.

Dr. Philipp Knebel

1,079

Federal Joint Committee (G-BA): Participation-related goal achievement through remedies and equipment with mobility-restricting paralysis syndromes (NeuroMoves)

Prof. Dr. Norbert Weidner
PD. Dr. Rüdiger Rupp
Prof. Dr. Michael Wensing

1,054

Else Kröner-Fresenius-Stiftung: Else Kröner-Research Schools: Heidelberg Research School for Neurooncology

Prof. Dr. Wolfgang Wick

1,000

Junior Development Programs at the Faculty of Medicine

Program

Goal/Content

Support

MD/PhD

Structured doctoral program in biology, natural sciences and clinical work for students of human medicine and dentistry after they have completed the first part of the state examination in medicine or the preliminary dental medicine examination

4 newly admitted students

Physician Scientist

Protected research time with simultaneous relief from clinical work for physicians who have obtained their doctorates. Three-year program, the Medical Faculty finances two years of research time. The third year is for clinical advanced training and is financed by the department.

13 places approved

Rotation Jobs
Dentistry

Support for junior researchers in dentistry

3 place approved

Curriculum
Clinical Research

Modular qualification program for co-workers who are involved in the implementation of clinical trials.

Absorption of the qualification costs

MEDISS
(Medical Structured Scientific Program)

Faculty-wide, structural doctoral program to support the academic exchange with experienced scientists, good scientific practice, and specialized courses

For all medical and dental PhD students

Gender Equality

Program

Goal/Content

Support

Olympia Morata

Postdoctoral qualification program qualified female researchers/physicians; protected research time: 2 years, 50 % of the position

6 approvals

Rahel Goitein-Straus

Support for the transition of female physicians/researchers to their first independent research work; protected research time: 1 year, 50 % of the position

5 approvals

Short-Term Grants

Support for research activities by women during or even after their residencies; protected research time: 3-6 months

7 approvals

Mentoring Program

For female researchers and physicians with modular management training and competency seminars as well as mentoring by experienced leaders

10 participants

Internal Research Support Programs

Program

Goal/Content

Support

"Third-Party Funding“
Bonus Program

Researchers will receive a bonus for the acquisition of third-party funding for biomedical projects, which were awarded in a recognized evaluation procedure

About 4.24 m €

Bonus Program Leading Publications

Bonus for publications on research results which were predominantly developed at a facility of the Medical Faculty at the University of Heidelberg

About 200 K €

Research/ Investment Funds

Strengthening of research infrastructure. In 2020, the focus was on large-scale research equipment